BNCT Cancer Therapy
Precision radiation treatment at the cellular level — targeting tumours while sparing healthy tissue.
The Challenge
Cancer Treatment That Spares Healthy Tissue
Conventional radiation therapy cannot distinguish between tumour cells and surrounding healthy tissue. For head and neck cancers — often located near critical structures like the brain, eyes, and airway — this limits dose delivery and treatment efficacy. Recurrent cases after prior radiation are particularly difficult, with few remaining options. India has over 200,000 new head and neck cancer cases annually, the highest incidence in the world. Yet there is no BNCT facility anywhere in the country, forcing patients to seek treatment abroad or accept suboptimal alternatives.
Our Approach
Cellular-Precision Neutron Therapy
ASPL Fusion is building India’s first accelerator-based BNCT facility. A proton accelerator generates epithermal neutrons through a carefully engineered Beam Shaping Assembly (BSA). A boron compound administered to the patient accumulates preferentially in tumour cells. When irradiated, the boron captures neutrons and releases high-energy alpha particles with a range of just one cell diameter — destroying only the tumour while leaving adjacent healthy tissue intact.
Our BSA design is informed by a knowledge graph of over 6,400 published papers on beam shaping and BNCT, covering every major clinical facility worldwide including NeuCure, CICS-1, and Neutron Therapeutics.
Why It Matters
Key Benefits
Cellular Precision
Radiation damage is confined to a single cell diameter. Healthy tissue adjacent to the tumour receives minimal dose — critical for cancers near the brain, eyes, and airway.
Recurrent Cancer Treatment
BNCT can treat tumours that have already received conventional radiation therapy — offering hope for patients with limited remaining options.
Single-Session Potential
Unlike conventional radiation delivered over weeks, BNCT treatment is typically completed in one or two sessions, reducing patient burden and hospital resource requirements.
Who This Serves
Industries & Applications
- Oncology hospitals and cancer research centres treating head and neck cancers
- Neurosurgery departments managing recurrent glioblastoma
- Radiation oncology teams seeking alternatives for radiation-resistant tumours
- Clinical trial organisations exploring next-generation radiation therapies
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Related Applications
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